How does life bootstrap before there are genes? Kauffman’s answer: a collectively autocatalytic set — a group of molecules where every member’s formation is catalyzed by another member of the set. No single molecule copies itself; the whole set catalyzes its own reproduction, a closed loop of mutual creation. Above a critical ratio of reactions to molecules it emerges almost inevitably — “order for free.”
The demo checks catalytic closure on a 3-molecule set where A→B→C→A each catalyze the next: live demo
“Life needed a self-copying molecule first.” — an autocatalytic set reproduces collectively with no individual self-replicator; catalytic closure suffices. cited
Reproduction without a replicator. origin of life
On i-13, a 3-cycle where each member catalyzes the next has full catalytic closure: